Diverse roles of heterogeneous nuclear ribonucleoproteins in viral life cycle

K Bhattarai, M Holcik - Frontiers in Virology, 2022 - frontiersin.org
… of hnRNP D have differential effects on HIV-1 Gag expression… it to the plasma membrane for
virion assembly (177, 192, 193)… hnRNPs involvement on viral RNA trafficking and packaging …

Genome-wide analysis of heterogeneous nuclear ribonucleoprotein (hnRNP) binding to HIV-1 RNA reveals a key role for hnRNP H1 in alternative viral mRNA splicing

SB Kutluay, A Emery, SR Penumutchu… - Journal of …, 2019 - Am Soc Microbiol
… Notably, HIV-1 infection may prevent the assembly of stress … the RNAi-mediated knockdown
of hnRNPs might alter HIV-1 … of hnRNP H1 binding sites would affect viral gene expression. …

Retroviral hijacking of host transport pathways for genome nuclear export

RT Behrens, NM Sherer - Mbio, 2023 - Am Soc Microbiol
… or induction of virus-induced cell stresses that otherwise impact the … (110) linked HIV-1 RNA
trafficking to intracellular … of HIV-1 Rev and its primary role in HIV-1 gene expression, it was …

Nuclear pore heterogeneity influences HIV-1 infection and the antiviral activity of MX2

M Kane, SV Rebensburg, MA Takata, TM Zang… - Elife, 2018 - elifesciences.org
… HeLa and HT1080 cell lines that expressed MX2 in a doxycycline-… effects of MX2, cell cycle
arrest, and CypA/CsA on HIV-1trafficking both within and between cells that influences viral

Role of Host Factors in the Subcellular Trafficking of Gag Proteins and Genomic RNA Leading to Virion Assembly

EC Chen, LJ Parent - Retrovirus-Cell Interactions, 2018 - Elsevier
expression of viral proteins or assembly of new virusheterogeneous nuclear ribonucleoprotein
(hnRNP) family have been identified to play a role in the trafficking of HIV-1 genomic RNA

Multiple functions of heterogeneous nuclear ribonucleoproteins in the positive single-stranded RNA virus life cycle

J Wang, D Sun, M Wang, A Cheng, Y Zhu… - Frontiers in …, 2022 - frontiersin.org
HnRNP A/B are responsible for RNA splicing, trafficking and … However, a study indicated
that hnRNP K could affect viral … Thus, hnRNP proteins modulate HIV-1 gene expression by a …

HIV-1 Tat commandeers nuclear export of Rev-viral RNA complex by controlling hnRNPA2-mediated splicing

S Yandrapally, S Sarkar, S Banerjee - Journal of Virology, 2023 - Am Soc Microbiol
… that dictates nucleocytoplasmic trafficking of Rev-RNA complex and virion production during
expression. These regulatory proteins, such as heterogeneous nuclear ribonucleoprotein (…

Viral–host interactions during splicing and nuclear export of influenza virus mRNAs

M Esparza, P Bhat, BMA Fontoura - Current opinion in virology, 2022 - Elsevier
… has a role in viral intracellular trafficking and as a structural … with heterogeneous nuclear
ribonucleoprotein K (hnRNP K), … virus 1 tat/rev exon 3 leads to the discovery of a new HIV-1

Heterogeneous nuclear ribonucleoprotein K promotes cap-independent translation initiation of retroviral mRNAs

Y Fuentes, V Olguín, B López-Ulloa… - Nucleic Acids …, 2024 - academic.oup.com
… of the HIV-1 5 UTR in HIV-1 IRES-mediated translation initiation … the impact of HAhnRNPK
on RLuc and FLuc expression from … protein-protein interactions, favoring the assembly of an ef…

The importance of virion-incorporated cellular RNA-Binding Proteins in viral particle assembly and infectivity

K Dicker, AI Järvelin, M Garcia-Moreno… - Seminars in Cell & …, 2021 - Elsevier
… and expression; and (3) assembly and egress of the virus … (EEF), heterogeneous nuclear
ribonucleoproteins (HNRNP) or … of HIV-1 particles [109], and ARF1 regulates HIV-1 trafficking to …